OK. To be honest, in a perfect world I would draw every panel of Anecrophilia with a quill pen and a bottle of India Ink, transfer them to my computer by way of a top of the line scanner, touch them up with a nice image program, and then transfer the characters onto the painstakingly hand painted backgrounds, possibly done in watercolor by an army of slaves. Oh, and then I'd have the end result transfered carefully to meter wide fine silk tapestries or something too.

Meanwhile, in the real world, Anecrophilia is drawn with a mouse in the most primitive image editor you'll ever see, and saved in a web-safe file format for people to look at on this site. That said, there are a few things people have mentioned they'd like to see me do differently. So, here's one of the more complex panels I have sitting around, saved in four different ways:

Method 1	Method 2
This is how I do things now. Nice little gifs. The comic as a whole has a width of 700 pixels (800 if I get around to doing borders), so nobody has to scroll horizonally... unless they have less than 800 pixels to work with I suppose.	Here's a common suggestion. Switch over to pngs instead. The files are actually smaller, and there are absolutely no changes resulting from image compression. Personally though, I actually like the textures that result from saving as gifs. If I did this sort of thing, I'd have to spend more time adding in textures by hand... of course, I really should do that anyway.
Method 3
Moving on to another comment people have, here's the size at which I actually drew this panel. I shrink everything down to half-width, both to fit everything in one screen for those with lower resolutions, and to help mask the roughness of lines. Oh yes, and bear in mind that if I went with bigger images, I would likely still do the 50% shrink, I'd just draw at a bigger size to start with, so you'd never end up with something that looks this blurry.
Method 4
Finally, this is what the master images look like before I start preparing them for posting. The one high tech trick I apply is an unsharpenning filter, which serves as a poor man's method of antialiasing. I really like the effect of this one, so good luck talking me out of it.

So, the issues here again are, should I switch everything over to .png? Yes, no, leave issue 1 gif but switch for the future. Do you think I should go with bigger panels? If so, how wide do you want the comic as a whole? As is, it's 700 pixels, 800 with a border. Anyway, send all thoughts on the matter here.